{"id":10513,"date":"2018-09-12T22:33:10","date_gmt":"2018-09-12T22:33:10","guid":{"rendered":"http:\/\/www.eurekaone.com\/s6-en-articoli\/c42-en-kits-in-hplc\/farmacologia-clinica-2\/"},"modified":"2025-06-18T12:24:17","modified_gmt":"2025-06-18T10:24:17","slug":"farmacologia-clinica-hplc-2","status":"publish","type":"post","link":"https:\/\/www.eurekakit.com\/en\/farmacologia-clinica-hplc-2\/","title":{"rendered":"Therapeutic Drug Monitoring"},"content":{"rendered":"

Therapeutic Drug Monitoring<\/h2>\n

Pharmacological treatments and their side effects can have an impact on the patients\u2019 safety or life\u2019s quality. Specifically, the so called ADME (absorption, distribution, metabolism, and excretion) of the drug can be highly influenced by the genetics, environment and administration of other drugs due to co-morbidities. Therefore, in some cases the treatment with a fixed drug dose can turn out risky for patients\u2019 health. For this reason, the Monitoring of a drug therapy which is optimized for a specific case is necessary.<\/span>
\nOn one hand, this can be particularly needed for drugs that present a narrow therapeutic range, which can be easily exceeded causing many toxic effects and\/or increasing drugdrug interactions (DDIs) (Tuzimski, et al. 2020_review). On the other hand, if the drug concentration is lower than the safety ranges the pharmacological activity might not occur.<\/span>
\nIn the light of this, Therapeutic Drug Monitoring (TDM) is a strategic way to \u201cadjust\u201d the treatment and the dose based on patient\u2019s clinical case (Kuhlin_cMSpec_2018).<\/span><\/p>\n

\u00a0<\/span><\/p>\n

For a long time, immunoassays have been chosen as methods for TDM. However, the necessity to analyze specific metabolites and to avoid non-specific interference coming from other molecules or matrix led to switch to an alternative method which provides high selectivity and sensitivity, high-quality data and reproducibility. This has been found in liquid chromatography methods coupled with UV, fluorescence detectors (FLD) or MS detectors triple quad (Mass Spectrometry). Liquid chromatography coupled with tandem mass spectrometry (LC-MS\/MS) techniques allows to analyze drugs with high selectivity and sensitivity.<\/span><\/p>\n\n\n\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\"\"<\/td>\n<\/tr>\n
<\/td>\nANTIEPILEPTICS
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nLamotrigine in serum and in plasma by UV – FAST<\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\nLamotrigine and 10,11-Dihydro-10-Hydroxycarbazepine\u00a0 in serum and in plasma by UV – FAST <\/a><\/strong>(100 tests)<\/a>
\n<\/a><\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nLevetiracetam in plasma by UV – FAST<\/strong> <\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\nPerampanel in plasma by Fluorimetry – FAST <\/strong><\/a>(100 tests)<\/a>
\n<\/strong><\/a><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nTopiramate in plasma by Fluorimetry<\/a><\/strong> (100 tests)<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\nValproic Acid in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n\n

\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\"\"<\/td>\n\n

Antiepileptics 1 in serum and in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

(Phenobarbital, Phenytoin and Carbamazepine )<\/a><\/em><\/p>\n<\/td>\n<\/tr>\n

\"\"<\/td>\n\n

Antiepileptics 3 in serum and in plasma by UV – FAST<\/strong> <\/a>(100 tests)<\/a><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

(Ethosuximide, Primidone, Lamotrigine, Phelbamate, 10,11-Dihydro-10-Hydroxycarbazepine,
\nCarbamazepine-epoxide, Oxacarbazepine)<\/a><\/em><\/p>\n<\/td>\n<\/tr>\n

\"\"<\/td>\nAntiepileptics 4 in serum and in plasma by UV – FAST<\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Lamotrigine, Zonisamide, Monohydroxycarbazepine)<\/a><\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics 5 in serum and in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Lacosamide, Rufinamide, Desmethylsuximide, Metosuximide, Phenytoin)<\/a><\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics 6 in serum and in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Lacosamide, Ethosuximide, Zonisamide, Primidone, Lamotrigine , 10,11-Dihydro-10-Hydroxycarbamazepine)<\/a><\/em><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\nANTIARRYTHMICS
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nAmiodarone\/Desethylamiodarone in serum and in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiarrythmics in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Flecainide,<\/a><\/em> P<\/a><\/em>ropafenone,<\/a><\/em> Verapamil)<\/a><\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nSotalol\u00a0 in plasma by Fluorimetry FAST<\/strong><\/a>\u00a0 (100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\nDRUGS FOR PANIC, ANXIETY OR MENTAL DISORDERS
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nBenzodiazepines 1 in serum and in plasma by UV – FAST <\/a><\/strong>(100 tests)<\/a>
\n<\/strong><\/td>\n<\/tr>\n
<\/td>\n\n

(Bromazepam, Lorazepam, Clonazepam, Flunitrazepam, Clordemetildiazepam)<\/a><\/em><\/p>\n<\/td>\n<\/tr>\n

\"\"<\/td>\n\n

Benzodiazepines 2 in serum and in plasma by UV – FAST <\/strong><\/a>(100 tests)<\/a><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

(Nordiazepam, Clobazam, Diazepam)<\/a><\/em><\/p>\n<\/td>\n<\/tr>\n

\"\"<\/td>\nClozapine and Norclozapine in serum and in plasma by UV – FAST<\/a><\/strong><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
\"\"<\/td>\n\n

Tricyclic Antidepressants in serum and in plasma by UV <\/strong><\/a>(100 tests)<\/a><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

(Nordoxepine, Desipramine, Imipramine, Doxepine, Amitriptiline and Nortriptiline)<\/a><\/em><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/td>\n<\/tr>\n
<\/td>\nIMMUNOSUPPRESSANT<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nMychophenolic Acid\u00a0 in serum and in plasma by UV – FAST<\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/strong><\/td>\n<\/tr>\n
<\/td>\nANTI-INFECTIVE DRUGS
\n<\/strong><\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nAntibiotics in plasma by UV – FAST <\/a>(100 tests)<\/a><\/strong><\/td>\n<\/tr>\n
<\/td>\n(Ceftriaxone, Ampicillin, Ciprofloxacin, Levofloxacin, Linezolid, Piperacillin, Tazobactam, Ceftazidime, Meropenem, Cefoxitine, Daptomycin)<\/em><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nAntimycotics in plasma by Fluorimetry – FAST <\/a><\/strong><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Posaconazole, Voriconazole, Itraconazole, OH-Itraconazole)<\/span><\/em><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/em><\/td>\n<\/tr>\n
<\/td>\nANTI-DIABETES DRUGS<\/strong>
\n<\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nMetformin in serum by UV\/VIS – FAST <\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\"Torna<\/td>\n<\/td>\nback to previous page<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Therapeutic Drug Monitoring Pharmacological treatments and their side effects can have an impact on the patients\u2019 safety or life\u2019s quality. Specifically, the so called ADME (absorption, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,3],"tags":[],"class_list":["post-10513","post","type-post","status-publish","format-standard","hentry","category-non-categorizzato","category-uncategorized"],"yoast_head":"\nTherapeutic Drug Monitoring - Eureka Kit<\/title>\n<meta name=\"description\" content=\"In the light of this, Therapeutic Drug Monitoring (TDM) is a strategic way to \u201cadjust\u201d the treatment\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurekakit.com\/en\/farmacologia-clinica-hplc-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Therapeutic Drug Monitoring - 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