{"id":1927,"date":"2006-10-12T22:33:10","date_gmt":"2006-10-12T22:33:10","guid":{"rendered":"http:\/\/www.eurekaone.com\/s6-en-articoli\/c49-en-kits-lcms\/farmacologia-clinica-4\/"},"modified":"2025-04-03T15:51:30","modified_gmt":"2025-04-03T13:51:30","slug":"farmacologia-clinica-4","status":"publish","type":"post","link":"https:\/\/www.eurekakit.com\/en\/farmacologia-clinica-4\/","title":{"rendered":"THERAPEUTIC DRUG MONITORING LC\/MS"},"content":{"rendered":"

Therapeutic Drug Monitoring LC\/MS<\/h2>\n

Pharmacological treatments and their side effects can have an impact on the patients\u2019 safety or life\u2019s quality. Specifically, the so called ADME (absorption, distribution, metabolism, and excretion) of the drug can be highly influenced by the genetics, environment and administration of other drugs due to co-morbidities. Therefore, in some cases the treatment with a fixed drug dose can turn out risky for patients\u2019 health. For this reason, the Monitoring of a drug therapy which is optimized for a specific case is necessary.
\nOn one hand, this can be particularly needed for drugs that present a narrow therapeutic range, which can be easily exceeded causing many toxic effects and\/or increasing drugdrug interactions (DDIs) (Tuzimski, et al. 2020_review). On the other hand, if the drug concentration is lower than the safety ranges the pharmacological activity might not occur.
\nIn the light of this, Therapeutic Drug Monitoring (TDM) is a strategic way to \u201cadjust\u201d the treatment and the dose based on patient\u2019s clinical case (Kuhlin_cMSpec_2018).<\/p>\n

For a long time, immunoassays have been chosen as methods for TDM. However, the necessity to analyze specific metabolites and to avoid non-specific interference coming from other molecules or matrix led to switch to an alternative method which provides high selectivity and sensitivity, high-quality data and reproducibility. This has been found in liquid chromatography methods coupled with UV, fluorescence detectors (FLD) or MS detectors triple quad (Mass Spectrometry).Liquid chromatography coupled with tandem mass spectrometry (LC-MS\/MS) techniques allows to analyze drugs with high selectivity and sensitivity.<\/p>\n

 <\/p>\n\n\n\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\"\"<\/td>\n<\/tr>\n
<\/td>\nIMMUNOSUPPRESSANTS
\n<\/strong><\/em><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nImmunosuppressants in whole blood by LC\/MS – <\/strong>(100 tests<\/a>)<\/td>\n<\/tr>\n
<\/td>\n(Cyclosporin A, Everolimus, Sirolimus, Tacrolimus)
\n<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nImmunosuppressants in whole blood by LC\/MS –\u00a0 <\/strong>(500 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Cyclosporin A, Everolimus, Sirolimus, Tacrolimus)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nImmunosuppressants DUAL KIT in whole blood\/Plasma by LC\/MS – <\/strong>(100 tests)\u00a0<\/a><\/td>\n<\/tr>\n
<\/td>\n(Cyclosporin A, Everolimus, Mycophenolic Acid, Sirolimus, Tacrolimus)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nImmunosuppressants DUAL KIT in whole blood\/Plasma by LC\/MS –\u00a0 <\/strong>(200 tests)\u00a0<\/a><\/td>\n<\/tr>\n
<\/td>\n(Cyclosporin A, Everolimus, Mycophenolic Acid, Sirolimus, Tacrolimus)<\/em><\/td>\n<\/tr>\n
\"\"<\/em><\/td>\nImmunosuppressants DUAL KIT in whole blood\/Plasma by LC\/MS –\u00a0<\/strong><\/a> (500 tests)<\/td>\n<\/tr>\n
<\/td>\n(Cyclosporin A, Everolimus, Mycophenolic Acid, Sirolimus, Tacrolimus)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nBenzodiazepines in serum by LC\/MS <\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Bromazepam, Lorazepam, Clonazepam, Flunitrazepam, Chlordemethyldiazepam, Nordiazepam, Clobazam, Diazepam, Midazolam, Nitrazepam, Oxazepam, Flurazepam, Triazolam, Norclobazam, Zopiclone, Trazodone, Demoxepam, Chlordiazepoxide)<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nBenzodiazepines and Barbiturates in urine by LC\/MS (100 test)<\/a><\/strong>
\n<\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n(Allobarbital, Alprazolam, Amobarbital, Barbital, Bromazepam, Butalbital, Cathinone, Clobazam, Clonazepam, Cocaethylene, Diazepam, Hexobarbital, Fentanyl, Flunitrazepam, Hydroxy-Alprazolam, Hydroxy-Bromazepam, Lorazepam, Lormetazepam, Lsd, Mescaline, Nordiazepam, Norketamine, Oxazepam, Pentobarbital, Secbutarbital, Secobarbital, Temazepam, Thiopental)<\/em><\/td>\n<\/tr>\n
<\/td>\nANTIARRHYTHMICS<\/strong><\/td>\n<\/tr>\n
<\/td>\n<\/td>\n<\/tr>\n
\"\"<\/td>\nAntiarrhythmics in serum and in plasma by LC\/MS<\/strong><\/a><\/td>\n<\/tr>\n
<\/td>\n(Amiodarone, Desethylamiodarone, Flecainide, Propafenone, Sotalol, Quinidine)<\/em><\/td>\n<\/tr>\n
<\/td>\nANTI-INFECTIVE DRUGS<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\n\u00a0Antibiotics in plasma by LC-MS\/MS –\u00a0<\/strong><\/a> (100 tests)<\/td>\n<\/tr>\n
<\/td>\n(Amikacin, Ceftazidime, Ciprofloxacin, Daptomycin, Gentamicin, Levofloxacin, Linezolid, Meropenem, Streptomycin, Teicoplanin, Vancomycin)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntibiotics in plasma by LC-MS\/MS –\u00a0<\/a> <\/strong>(<\/a>500 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Amikacin, Ceftazidime, Ciprofloxacin, Daptomycin, Gentamicin, Levofloxacin, Linezolid, Meropenem, Streptomycin, Teicoplanin, Vancomycin<\/span>)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntimycotics in plasma by LC-MS\/MS –<\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n((5-Flucytosine, Anidulafungin, Caspofungin, Fluconazole, Hydroxy- Itraconazole, Isavuconazole, Itraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntituberculosis Drugs in plasma by LC\/MS <\/a><\/strong>(100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\nANTIEPILEPTICS
\n<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics in serum \/ in plasma by LC\/MS – <\/a> <\/strong>(<\/a>100 tests)<\/a><\/td>\n<\/tr>\n
<\/td>\n(Levetiracetam, Lamotrigine, Primidone, Oxcarbazepine, Carbamazepine Epoxide, 10,11-Dihydro-<\/em>10-Hydroxy-Carbamazepine, Carbamazepine, Phelbamate, Desmethylsuximide, Rufinamide, <\/em>Phenytoin, Methsuximide, Topiramate, Phenobarbital, Valproic Acid, Ethosuximide, Lacosamide, <\/em><\/span>Zonisamide, Perampanel, Sulthiame, Pregabalin, Brivaracetam, Gabapentin, Stiripentol, <\/strong><\/em>Vigabatrin, Tiagabine<\/strong>)<\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics in serum \/plasma by LC\/MS –\u00a0<\/strong><\/a> (500 tests)<\/td>\n<\/tr>\n
<\/td>\n(Levetiracetam, Lamotrigine, Primidone, Oxcarbazepine, Carbamazepine Epoxide, 10,11-Dihydro-<\/span><\/a>10-Hydroxy-Carbamazepine, Carbamazepine, Phelbamate, Desmethylsuximide, Rufinamide, Phenytoin, Methsuximide, Topiramate, Phenobarbital, Valproic Acid, Ethosuximide, Lacosamide, Zonisamide, Perampanel, Sulthiame, Pregabalin, Brivaracetam, Gabapentin, Stiripentol, Vigabatrin, Tiagabine)<\/strong><\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/span><\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics in plasma by LC\/MS –\u00a0<\/strong><\/span><\/span> (100 tests)<\/span><\/span><\/a><\/td>\n<\/tr>\n
<\/td>\nLevetiracetam, Lamotrigine, Primidone, Oxcarbazepine, Carbamazepine Epoxide, 10,11-Dihydro-10-Hydroxy-Carbamazepine, Carbamazepine, Phelbamate, Desmethylsuximide, Rufinamide, Phenytoin, Methsuximide, Topiramate, Phenobarbital, Valproic Acid, Ethosuximide, Lacosamide, Zonisamide, Perampanel)<\/span><\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/span><\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nAntiepileptics in plasma by LC\/MS –\u00a0<\/strong> (500 tests)<\/span><\/span><\/a><\/td>\n<\/tr>\n
<\/td>\nLevetiracetam, Lamotrigine, Primidone, Oxcarbazepine, Carbamazepine Epoxide, 10,11-Dihydro-10-Hydroxy-Carbamazepine, Carbamazepine, Phelbamate, Desmethylsuximide, Rufinamide, Phenytoin, Methsuximide, Topiramate, Phenobarbital, Valproic Acid, Ethosuximide, Lacosamide, Zonisamide, Perampanel)<\/span><\/em><\/span><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/span><\/em><\/span><\/td>\n<\/tr>\n
<\/td>\nCHEMOTHERAPY DRUGS<\/strong>
\n<\/span><\/em><\/span><\/td>\n<\/tr>\n
\"\"<\/td>\nTamoxifen, Endoxifen in plasma by LC\/MS – <\/a> <\/strong>(100 tests)<\/a>
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\n5-Fluorouracil in PBMC by\u00a0 LC-MS\/MS <\/a><\/strong>(100 tests)<\/a>
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\n Irinotecan in plasma by LC-MS\/MS – <\/a> <\/strong>(100 tests)<\/a>
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nPonatinib in plasma by\u00a0 LC-MS\/MS (100 tests)\u00a0<\/a> <\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u00a0<\/strong><\/td>\n<\/tr>\n
<\/td>\nDRUGS FOR PANIC, ANXIETY OR MENTAL DISORDER
\n<\/strong><\/td>\n<\/tr>\n
\"\"<\/td>\nAntidepressants in serum \/plasma by LC\/MS <\/strong><\/a><\/td>\n<\/tr>\n
<\/td>\n(Amitriptyline, Citalopram and Escitalopram, Clomipramine, Desipramine, Desvenlafaxine, Doxepine, Duloxetine, Fluoxetine, Fluvoxamine, Imipramine, Norclomipramine, Nordoxepine, Norfluoxetine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine)<\/em><\/td>\n<\/tr>\n
\"\"<\/td>\nAntipsychotics in plasma \u00a0by LC\/MS –<\/a> <\/strong><\/td>\n<\/tr>\n
<\/td>\n(<\/em>Quetiapine, Aripiprazole, Olanzapine, Risperidone, Haloperidol, Clozapine, Norclozapine, Paliperidone, Fluphenazine, Ziprasidone)<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\"Torna <\/a><\/td>\n<\/td>\nback to previous page<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Therapeutic Drug Monitoring LC\/MS Pharmacological treatments and their side effects can have an impact on the patients\u2019 safety or life\u2019s quality. Specifically, the so called ADME […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1927","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nTHERAPEUTIC DRUG MONITORING LC\/MS - Eureka Kit<\/title>\n<meta name=\"description\" content=\"Therapeutic Drug Monitoring (TDM) is a strategic way to \u201cadjust\u201d the treatment and the dose based on patient\u2019s clinical case\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.eurekakit.com\/en\/farmacologia-clinica-4\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"THERAPEUTIC DRUG MONITORING LC\/MS - 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