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Indican in urine by Fluorimetry – FAST (code Z60110) – 100 tests package.
INSIGHTS
Indican is a product of tryptophan metabolism. Tryptophan is first converted to indole. Following absorption from the gut, indole is hydroxylated in the liver and conjugated with sulfuric acid or glucoronic acid. Finally, it is excreted in urine as Indican. The levels of urinary Indican are usually low in clinically healthy individuals (eubiosis). Instead, if there is an imbalance between micro-organisms, a condition called dysbiosis occurs. Some of the symptoms are: poor digestion, swelling, halitosis, increased susceptibility to infections, as well as nervousness, anxiety, sleep disorders and fatigue. The values of Indican present in urine can undergo variations. In particular, an increase occurs in cases of steatorrhea due to pancreatic insufficiency treated with pancreatic enzyme extract, and Hartnup disease, a rare genetic disease characterized by intestinal and renal malabsorption of some amino acids. Furthermore, high levels of this analyte are correlated with a rapid progression of chronic kidney disease in non-dialysate uremic patients. Oral antibiotics, on the other hand, can decrease urinary Indican.
Principle of the Method:
The Indican is analyzed by treating the urine with a suitable diluent and the resulting solution is directly injected into HPLC.
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