Ethylglucuronide in hair by LC/MS

Ethylglucuronide  in hair by LC/MS (code  LC95010) – 50 tests package.

INSIGHTS

Ethyl glucuronide is a non-volatile molecule, polar, relatively stable and formed by conjugation of Ethanol with Glucuronic Acid with mediation of UDP-glucuronyl-transferase (UGT), a superfamily of highly polymorphic enzymes.The Ethylglucuronide seems to be synthesized by various isoforms with UGT function. The lack of one of these isoforms in an individual, does not indicate significant variations in the formation of Ethyl glucuronide. Therefore, individuals belonging to different ethnic groups, most likely synthetize the same percentage of the compound after Alcohol consumption. It has been estimated that only 0.02-0.06 % of Ethanol consumed is transformed into Ethyl glucuronide.

Principle of the  Method:

This method enables the Ethylglucuronide after hydrolysis of hair, in liquid phase and reading extraction in LC/MS.
The method was validated according to the criteria established at international level by the FDA and the ICHLC-MS.

	IFU
	IFU MOBILE PHASE M1
	IFU MOBILE PHASE M2