3-Nitrotyrosine in plasma by UV – FAST (code  Z61010) – 100 tests package.

INSIGHTS
3-nitrotyrosine is found in many pathological conditions and is considered as a marker of oxidative stress dependent on NO. Nitrotyrosine is found in many tissues affected by diseases, such as the cornea and keratoconus. It is most likely involved in the process of pathogenesis of diabetes. It is identified as an indicator of cell damage and inflammation, as well as an index of NO production. It is believed that measuring the concentration of nitrotyrosine serves as a marker for the damage caused by NO in the cell. Previous studies have shown that nitrotyrosine is found in inflammatory conditions such as atherosclerotic plaques and rheumatoid arthritis.

Principle of the method :

This method is used to determine plasma concentrations of 3-Nitrotyrosine. To an aliquot of plasma is added a reagent Precipitation and after the addition of a reducing agent, the sample is transferred into the test tube and injected into HPLC.

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