Antiarrhythmics in plasma by UV – FAST

Antiarrhythmics in plasma by UV – FAST (Flecainide, Propafenone, Verapamil) (code  Z78010) – 100 tests package.

INSIGHTS
Flecainide is a class IC antiarrhythmic drug according to the classification of Vaughan-Williams. It works by slowing the myocardial cell depolarization (phase 0), primarily on the conduction system of the His-Purkinje (conduction H-V) and, to a lesser extent, the nodal conduction and atrioventricular septal. Propafenone is anti-arrhythmic drug blocking sodium channels (Class IC). Its predominant effect is thus made by depression of the conduction velocity at the level of all the cardiac structures. Verapamil is an inhibitor of transmembrane flows of calcium ion, attive on vascular smooth muscle and on myocyte in reducing myocardial contractility

Principle of the Method:

This method is used to determine plasma concentrations of Flecainide, Propafenone, Verapamil after purification SPE plasma; after the elution the sample is diluted with a suitable reagent (stabilization solution)and injected into the HPLC chromatograph.

	IFU
	IFU MOBILE PHASE