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Tricyclic Antidepressants in serum and in plasma by UV (Nordoxepine, Desipramine, Imipramine, Doxepine, Amitriptiline and Nortriptiline) (code Z56010) – 100 tests package. INSIGHTS Tricyclic Antidepressants (abbreviation TAD) are a class of antidepressant drugs first used in the 1950s. They are named after the drug’s molecular structure, which contains three rings of atoms. They are used in numerous applications; mainly indicated for the treatment of clinical depression, neuropathic pain, nocturnal enuresis and attention-deficit hyperactivity disorder (ADHD), etc. Tricyclic antidepressants overdose is a significant cause of fatal drug poisoning. Principle of the Method: The Tricyclic Antidepressants are isolated purifying the serum/plasma with a clean-up column. After the adding of a stabilization solution the eluate is directly injected into HPLC system.
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