Clozapine and Norclozapine in serum and in plasma by UV – FAST

Clozapine and Norclozapine in serum and in plasma by UV – FAST (code  Z76610) – 100 tests package.

INSIGHTS
Clozapine is an atypical neuroleptic drug, belonging to the chemical family of Di-Benzodiazepines, widely used in the treatment of persistent schizophrenia. Unlike other neuroleptics, it does not induce extrapyramidal side effects, despite its efficacy. Its use is limited because it may cause agranulocytosis. From research it has been found that plasmatic levels of Clozapine and Norclozapine are influenced by factors such as: gender, age, compliance, caffeine intake, smoking and pharmacological interactions.

Principle of the  Method:

This method is used to determine plasma concentrations of Clozapine and its metabolite, Norclozapine .At an aliquot of plasma (250 μl) is added a derivatization solution and a coprecipitant and, after centrifugation, the supernatant is transferred into the tube and injected into HPLC.

	IFU
	IFU MOBILE PHASE