Formic Acid in urine in GC/MS-head space

Formic Acid in urine in GC/MS-head space (code  GC74010) – 100 tests package.

INSIGHTS
Methanol is used in the production of cellulose, synthetic resins, formaldehyde, acetic acid and fuel. Methanol is distributed uniformly in tissues and blood; it is metabolized in the liver and excreted in urine as Formaldehyde, Formic Acid and CO2. The major toxicity of methanol is not due to the molecule but to metabolite, Formic Acid. Alcohol dehydrogenase is the first metabolic pathway that oxidizes Methanol into Formaldehyde. The subsequent oxidation of Formaldehyde to Formic Acid takes place through aldehyde dehydrogenase, an extremely fast reaction. After 6-18 hours from the time of exposure visual disturbances (pupillar oedema) and metabolic acidosis are observed: they are caused mainly by Formic Acid which is also the main cause of optic neuritis. The dosage of methanol is only useful if it’s done early, while the determination of formates is more useful and can be used as an index of the intoxication’s severity.

Principle of the Method:

This method enables you to determine, after derivatisation, urinary formic acid in GC/MS head space

IFU