Total Metanephrines in urine by Fluorimetry – FAST (Extractive Method)

INSIGHTS
The dosage of urinary metanephrines represents a reliable test for the screening of pheochromocytoma. These substances derive from the metabolism of catecholamines, hormones produced and secreted by medullary of the adrenal glands, in order to prepare the organism for stressful events. Pheochromocytoma is a tumor that affects adrenalin glands causing a hypersecretion of catecholamines; as a result, levels of Adrenaline and Noradrenaline increase, as do the respective metabolites, called metanephrines. They form inside the tumor and are secreted inconsistently by the tumor.

Principle of the Method :
The Metanephrines (NORMETANEPHRINE and METANEPHRINE), after purification with Clean up columns, are derivatized with 2 specific reagents and incubate at 70 °C for 15 minutes. The derivatized solution is injected in HPLC.  IFU IFU MOBILE PHASE