Free VMA/5-HIAA/HVA in urine by Fluorimetry – FAST

Free VMA/5-HIAA/HVA in urine by Fluorimetry – FAST (code  Z14610) – 100 tests package

INSIGHTS

The catabolic process of monoamines is in part neuronal and happens in the mitochondria and it is catalyzed by the Monoamine oxidase (MAO) and, partly extra neuronal for catecholamines, it is catalyzed by COMT.  In particular, we obtain dihydroxyphenylacetic acid from dopamine by the action of the MAO, which is transformed by COMT into Homovanillic Acid (HVA). 3,4-Dihydroxypropanoic originates from Noradrenaline and Adrenaline and by interacting with COMT we have the synthesis of Vanilmandelic acid (VMA). Values of these analytes out of the norm indicate the presence of Pheochromocytoma, paraganglioma or neuroblastoma. 5-hydroxyindolacetic acid (5-HIIA) is the principal final product of serotonin metabolism. The determination of its concentration in urine is utilized for the diagnosis of a neuroendocrine tumor.

Principle of the Method :
Vanillymandelic Acid, 5-Hydroxyindoleacetic Acid and Homovanillic Acid are diluted with a suitable diluent and directly injected into the HPLC System. IFU  IFU MOBILE PHASE