Irinotecan in plasma by LC/MS –

Irinotecan  in plasma by LC/MS (code  LC94010)  100 test package.

INSIGHTS
Irinotecan is an antineoplastic chemotherapy drug of the class of camptothecins (drugs extracted from the bark of Camptotheca acuminata). Actually, Irinotecan is a pro drug. Its activation occurs at a hepatic level thanks to the transformation effected by the enzymecarboxesterase in SN 38. Irinotecan and SN 38 are then eliminated mainly through the bile. Therefore, the dosage should be reduced in patients with hepatic insufficiency.

Principle of the  Method:

 Irinotecan and its primary active metabolite are analyzed by treating the plasma with a suitable deproteinization reagent. The solution is directly injected into the LC / MS.

	IFU
	IFU MOBILE PHASE M1
	IFU MOBILE PHASE M2