Mycophenolic Acid in serum and in plasma by UV – FAST

Mycophenolic Acid  in serum and in plasma by UV – FAST (code  Z01960) – 100 tests package.

INSIGHTS
Mycophenolic Acid or Mycophenolate is an immunosuppressant drug used to prevent rejection in organ transplantation. It was initially marketed as the prodrug mycophenolate mofetil to improve oral bioavailability. Mycophenolate mofetil is metabolized in the liver to active moiety mycophenolic acid. It inhibits Inosine monophosphate dehydrogenase, the enzyme which controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of B and T lymphocytes. Mycophenolate is potent and can be used in place of the older antiproliferative azathioprine. It is usually used as part of triple-therapy including a calcineurin inhibitor (cyclosporin or tacrolimus) and prednisolone.

Principle of the Method:

Mycophenolic Acid is  separated treating the serum/plasma with a suitable precipitant. After addition of a diluting solution, 100 μl of the eluate is directly injected into HPLC.

	IFU
	IFU MOBILE PHASE