Norbuprenorphine and Buprenorphine in urine by detector MS

Norbuprenorphine and Buprenorphine in urine by detector MS (code  GC44010) – 50 tests package.

INSIGHTS_
Buprenorphine is an analgesic with a long-time action, 25 to 40 times more potent than morphine. It is used in many cases as a drug replacement therapy in the detoxification of heroin addicts with doses ranging from 0.2 to 2 mg. Since 1996, a high number of deaths have been observed as a result of taking buprenorphine, often associated with other psychotropic drugs. Buprenorphine is metabolized through N-dealkylation to norbuprenorphine, which is glucuronidated and excreted in urine. Determinative screening in biological fluids (especially urine) is usually performed using immunometric techniques using monoclonal antibodies and subsequent staining with various reagents. Because these techniques can not rule out false positives, the positive screening must be confirmed by alternative technology. This is usually done with gas chromatography (GC) or liquid chromatography (LC) coupled with both specific and selective detector (UV, Fluorescent, MS).

Principle of the  Method:

This method allows to determinate the Buprenorphine and the Norbuprenorphine in urine (the main metabolite of Buprenorphine), after SPE extraction and reading by GC-MS.

	IFU