Pyridinium Cross-Links in urine by Fluorimetry FAST (Extractive Method)

Pyridinium Cross-Links in urine by Fluorimetry FAST (code  Z29610) – 100 tests package

INSIGHTS
Pyridinoline (Pyr) and deoxy-pyridinoline (D-Pyr) are two crosslinks of maturated collagen present in many connective tissues such as bones, cartilages, tendons, ligaments and the Aorta, however absent in collagen and epidermis. Both compounds are expelled with urine. These compounds derive exclusively from maturated collagen degradation and the expulsion does not seem to be influenced by diet. For all these reasons the dosage of urinary concentrations of Pyr and D-Pyr was proposed for the evaluation of bone re-absorption and pathologies that are linked to this phenomenon like osteoporosis, primary hyperparathyroidism and Paget syndrome, and for follow up of bones tumor metastasis.

Principle of the Method:

The Samples/ reconstitute Calibrator is hydrolyzed at 100 °C for 16 h or at 150 °C for 1 h.The hydrolyzed is purificated with Clean+up Columns and the eluate is directly injected into HPLC system.

	IFU
	IFU MOBILE PHASE