trans-1,2-Cyclohexanediol in urine by detector FID or MS (code  GC19310) – 100 tests package.

INSIGHTS
Trans 1,2 Cyclohexanediol is one of the products (together with 1,4 Cyclohexanediol) of the metabolism of Cyclohexane and it is present both in free form and conjugated form (circa 70%) in urine of individuals exposed to Cyclohexane but also Cyclohexanol and Cyclohexanone. In research conducted on individuals exposed to Cyclohexane, the various urinary metabolites were present in the following proportions: Cyclohexanol 0.5%, 1,2 Cyclohexanediol 23.4%, 1,4 Cyclohexanediol 11.3%. The same pattern is found following exposure to Cyclohexanol and Cyclohexanone.

Principle of the Method:

The present method determines the trans 1-2 Cyclohexanediol in urine using column chromatography with FID or MS detector after acid hydrolysis of urine and liquid-liquid extraction.

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